For human toxicity, cancer and non-cancer health impacts are considered separately as indicators of disability in USEtox. Cancer effects rely to a large extent on TD50 (the dose eliciting a 50% population response) values that indicate potency to develop a tumor. Cancer is one type of tumor-related disease outcome and strongly associated with mutagenic properties of a chemical. As for reproductive toxic effects, these are captured in non-cancer effect factors whenever underlying reproductive toxic test data are available. Since all underlying available test data per chemical should be used to derive USEtox effect factors from the lowest converted human lifetime dose per exposure route, all underlying effects are considered in USEtox.
